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16-Oct-2017 19:59

Because of the key role of ICAM-1 in BBB physiology, genetic variations in its gene or in the genes coding for its receptors may be involved in MS susceptibility and/or severity.Conflicting results on the role of ICAM-1 in MS susceptibility have been reported.We demonstrate that the genes encoding ICAM-1 receptors do not influence MS susceptibility or severity.ICAM-1 had a modest, but significant effect on MS genetic susceptibility, independent of HLA and disease severity.

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There were 5, 86 and 9 of alleles 1, 2 and 3, respectively, considering patient alleles.

When for a marker, the uncorrected P-value was below 5% in batch 1, the remaining 289 case–parent families (batch 2) were tested.

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